The Regen Files

🌍 The One Health concept emphasizes the connection between human, animal, plant, and environmental health.

🦠 Soils play a key role in One Health as a source of pathogens, beneficial microbes, and overall microbial diversity.

🌾 Beneficial soil microorganisms can enhance plant production of secondary metabolites like omega-3 fatty acids and linoleic acid, benefiting human and animal health.

🍽️ Diets shape the gut microbiome in humans and animals, with plant microbiota—often derived from soil—contributing to gut health.

🌍 Skepticism about agroecology and regenerative agriculture persists, despite strong evidence of their potential to repair ecosystems, build climate resilience, and produce nourishing food.

📈 Agroecological natural farming led to 49% higher farmer incomes, greater diet diversity, and 11% higher yields, showing the highest positive returns on public investment.

🌾 This study reinforces that regenerative approaches can be economically, environmentally, and socially beneficial while enhancing food security.

🌾 Agricultural practices that improve soil organic carbon and microbial biomass can increase crop phytochemicals linked to reduced chronic disease risk.

🌍 While boosting yields, conventional practices like synthetic fertilizers have degraded soil health, causing nutrient runoff, water contamination, algal blooms, and greenhouse gas emissions that drive climate change.

🔎 Sustainable soil health management can enhance both environmental and human health.

🌾 Soils are a key source of nutrients that sustain human and animal health.

🌍 Soil health influences food security and human exposure to pollutants and pathogens.

🍎 Deficiencies in vitamins and minerals from poor soil health contribute to malnutrition, obesity, and chronic diseases.

🔎 The report highlights how soil fertility supports nutritious food production and explores the environmental and health impacts of fertilizer misuse.

🌾 Industrial agriculture's reliance on fertilizers and pesticides harms soil microbial diversity, contributing to erosion and loss of arable land.

🌍 Plant and human microbiomes are connected—microbes from fruits and vegetables integrate into the human gut, influencing health.

🌱 Herbicides, fungicides, and pesticides disrupt plant microbiomes, similar to how antibiotics affect human gut health.

🌾 Microorganisms drive 80–90% of soil metabolism, aiding nutrient bioavailability and organic matter transformation.

🌱 Agricultural intensification reduces soil biodiversity, limiting plant-associated microbiota that mobilize nutrients.

🌍 Soil quality indicators include microbial biomass carbon, extracellular enzyme activity, fungi-to-bacteria ratio, and basal respiration rate.

🌿 Microbial-supported plant growth enhances nutrient uptake, pathogen suppression, and hormonal signaling in nutrient-deficient soils.

🥩 Nutrient content depends on soil health, farming practices, genetics, and climate. Pasture-raised livestock produce more nutrient-dense meat, milk, and eggs with higher CLAs, omega-3s, and vitamins A and E.

🌾 Processed foods, antibiotics, and pesticides harm gut health, mirroring damage to soil microbiomes. Biodiversity supports resilience in both ecosystems and human health.

🌱 Diverse diets and ecosystems strengthen health and land resilience. Regenerative agriculture links food and health, driving broader systemic change.

🌾 Industrial farming reduces nutritional quality and exposes humans to harmful chemicals and environmental pollutants, contributing to chronic disease and environmental degradation.

🌱 Regenerative organic agriculture improves soil health, increases nutrient density, and avoids synthetic chemicals and fertilizers—offering a healthier, more sustainable solution. It also enhances biodiversity, supports gut health, and helps mitigate climate change through improved carbon sequestration.

🌍 Strengthening collaboration between healthcare, agriculture, and policy sectors is key to building resilient food systems and improving public health.

🌱 Regenerative agriculture (RA) enhances soil health, biodiversity, and ecological stability by reducing synthetic inputs and supporting grazing livestock.

🛡️ Expanding access to RA certification, especially for marginalized producers, is critical to scaling impact.

🥦 Food Is Medicine (FIM) programs can promote planetary health by sourcing from organic and regenerative systems.

🌱 Regenerative Agriculture (RA) focuses on improving soil health and sequestering carbon with principles like: reducing agriculture’s external impacts, minimizing energy and input use, enhancing carbon sequestration, nutrient cycling, and ecosystem services, increasing biodiversity, and promoting social justice

📊 This scoping review suggests RA may increase micronutrient concentrations in crops like rice and tomatoes under specific practices (e.g., organic inputs, deficit irrigation). However, results vary based on geographic conditions and study design.

🌿 RA practices include: organic inputs (compost, manures), reduced tillage, crop rotations & cover crops, intercropping & biostimulants (e.g., fungi), deficit irrigation, and reducing pesticide and fertilizer use can improve farm health and decrease environmental pollution.

🌱 Animal and epidemiologic studies suggest that there may be adverse health effects from exposure to glyphosate, the most highly used pesticide in the world, and its metabolite aminomethylphosphonic acid (AMPA).

🌱 The vast majority of subjects sampled had detectable levels, and significant dietary sources in the American diet were identified.

🌱 The results of this study demonstrate that more than one-half of the human microbiome is intrinsically sensitive to glyphosate.

🌱 This current meta-analysis of human epidemiological studies suggests a compelling link between exposures to glyphosate-based herbicides and increased risk for non-Hodgkin lymphoma.

🚨 Pesticide exposure increases the risk of cancer, neurological issues, and other health problems.

👨‍🌾 Occupational exposure raises health risks due to prolonged pesticide contact.

🌬️ Long-term effects from low-dose pesticide exposure through inhalation and ingestion can accumulate over time.

🛡️ Regulations and safety protocols are essential for reducing health risks and protecting public health.

🦠 Glyphosate and its formulations can disrupt gut microbiota, affecting bacterial metabolism, intestinal permeability, and mucus secretion.

🏥 Glyphosate causes damage to the intestinal microvilli and lumen.

🧬 Glyphosate exposure leads to immunological, enzymatic, and genetic alterations in animal models.

🔋 Glyphosate harms lipid and energy metabolism, the circulatory system, and replication and repair processes.

⚠️ These changes may contribute to intestinal and systemic diseases, such as Crohn's and Alzheimer's.

📊 Scientific reviews in 2023 linked pesticides to cancer, neurotoxicity, reproductive issues, diabetes, chronic diseases, and more—disproportionately harming communities of color.

⚖️ Weak laws and regulations have contributed to major health and environmental crises, including biodiversity loss and the climate emergency.

🌱 Research supports organic practices as a viable, cost-effective path toward healthier ecosystems and communities.

🚫 Tweaking chemical-based practices isn’t enough—systemic changes are essential to protect public health and the environment.

💼 Current policies prioritize corporate profits over people and ecosystem sustainability.

🌱 Studies have linked glyphosate exposure to various health risks, including cancer, birth defects, and reproductive problems.

🛡️ The findings of this analysis led to the International Agency for Research on Cancer to classify glyphosate as a probable human carcinogen in 2015.

⚠️ This study provides the first evidence that glyphosate exposure may be associated with neurological health outcomes in the US adult population. Additional investigation is necessary to understand the potential mechanisms and clinical significance of these correlations.

🧪 Decades of research link organophosphates and N-methyl carbamates to lower sperm concentration.

📉 The consistent association with reduced sperm counts highlights a broader decline in male fertility.

🚨 Senior author Dr. Perry urges regulatory action to reduce exposure, citing over 25 years of evidence.

🧪 Higher childhood AMPA levels were linked to increased liver transaminases (+14%) and metabolic syndrome (+55%) at age 18.

🌾 Living near glyphosate-treated areas during early childhood raised the risk of metabolic syndrome in early adulthood.

🚨 Early glyphosate and AMPA exposure may contribute to liver and cardiometabolic issues, increasing the risk of serious diseases later in life.

📊 CHAMACOS findings: Previous research linked pesticide exposure to various health issues.

🚨 Atrazine, glyphosate, and metolachlor were consistently linked to higher risks of all cancers, colon cancer, and pancreatic cancer.

🧬 Boscalid was associated with leukemia, non-Hodgkin's lymphoma, and pancreatic cancer (high-risk regions) and lung cancer (low-risk).

🦠 Dimethomorph was tied to leukemia and non-Hodgkin's lymphoma (high-risk) and colon cancer (low-risk).

🩺 Dicamba is consistently linked to colon and pancreatic cancer.

🫀 Dimethenamid is linked to bladder cancer (low-risk) and pancreatic cancer when combined with dimethenamid-P.

🧪 Dinotefuran is associated with leukemia and non-Hodgkin's lymphoma, but not colon cancer.

🫁 Imazethapyr is linked to all cancers, colon cancer, and lung cancer.